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HRG (gene) : ウィキペディア英語版
HRG (gene)

Histidine-rich glycoprotein is a protein that in humans is encoded by the ''HRG'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3273 )
== Function ==

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.〔
HRG is thought to have multiple roles as a protein in the human blood, including roles in immunity, angiogenesis and coagulation.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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